N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Base Information

Chemical Name:N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate
CAS No.:1124212-25-4
Molecular Formula:C₂HF₃O₂*C₂₉H₃₈N₄O₃
Molecular Weight:604.67
Hs Code.:

Synonyms:N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

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Chemical Property of N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

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Technology Process of N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

There total 8 articles about N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124211-98-8
3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

: 6540-33-6
cyclobutylacetic acid

: 1124212-25-4
N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1124211-98-8
3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

: 6540-33-6
cyclobutylacetic acid

: 76-05-1
trifluoroacetic acid

: 1124212-25-4
N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: 3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide; cyclobutylacetic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124212-25-4
N-tert-butyl-3-((4-(4-(2-cyclobutylacetamido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

3.2: Cooling with ice

4.1: hydrogen / Raney 2800 nickel / methanol; water / 1.02 h / 20 °C / 760.05 Torr / Sealed flask

5.1: HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; Raney 2800 nickel; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;