3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Base Information

• Chemical Name: 3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide
• CAS No.: 1124211-98-8
• Molecular Formula: C₂₃H₃₀N₄O₂
• Molecular Weight: 394.517
• Mol file: 1124211-98-8.mol

Synonyms:3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Chemical Property of 3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

There total 6 articles about 3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyl-3-((4-(4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide (1124211-96-6) → 3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (1124211-98-8)

Guidance literature:

With hydrogen; Raney 2800 nickel; In methanol; water; at 20 ℃; for 1.01667h; under 760.051 Torr; Sealed flask;

Reference yield:

N-tert-butyl-3-(chloromethyl)benzamide (1094362-66-9) → 3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (1124211-98-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

3.2: Cooling with ice

4.1: hydrogen / Raney 2800 nickel / methanol; water / 1.02 h / 20 °C / 760.05 Torr / Sealed flask

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; Raney 2800 nickel; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate (1124211-94-4) → 3-((4-(4-aminobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide (1124211-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol / 4 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2.2: Cooling with ice

3.1: hydrogen / Raney 2800 nickel / methanol; water / 1.02 h / 20 °C / 760.05 Torr / Sealed flask

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; Raney 2800 nickel; In methanol; ethanol; dichloromethane; water;

upstream raw materials:

N-tert-butyl-3-((4-(4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

N-tert-butyl-3-(chloromethyl)benzamide

tert-butyl 4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carboxylate

3-(Chloromethyl)benzoyl chloride

Downstream raw materials:

N-tert-butyl-3-((4-(4-(3-(cyclopropylmethyl)ureido)benzoyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

3-((4-(4-benzamidobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

cyclopropylmethyl 4-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)phenylcarbamate 2,2,2-trifluoroacetate

N-tert-butyl-3-((4-(4-(3-isoxazol-3-ylureido)benzoyl)piperazin-1-yl)methyl)benzamide