3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid

Base Information

Chemical Name:3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid
CAS No.:1035216-75-1
Molecular Formula:C₂₂H₂₂ClN₃O₄
Molecular Weight:427.887
Hs Code.:

Synonyms:3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid

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Chemical Property of 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid

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Technology Process of 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid

There total 3 articles about 3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.9%

: 1035216-73-9
4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)aniline

: 23761-23-1
3-oxocyclobutanecarboxylic acid

: 1035216-75-1
3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid

Guidance literature:: 4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)aniline; 3-oxocyclobutanecarboxylic acid; With acetic acid; In methanol; at 20 ℃; for 0.0833333h;

With sodium cyanoborohydride; In methanol; at 20 ℃;

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1035216-75-1
3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / 0.33 h / 150 °C / microwave irradiation

2.1: acetic acid / methanol / 0.08 h / 20 °C

2.2: 20 °C

With benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol;

Reference yield:

: 1035216-81-9,1035218-35-9
(Z)-3-chloro-N'-hydroxy-4-isopropoxybenzimidamide

: 1035216-75-1
3-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / 0.33 h / 150 °C / microwave irradiation

2.1: acetic acid / methanol / 0.08 h / 20 °C

2.2: 20 °C

With benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol;