(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Base Information

Chemical Name:(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
CAS No.:1354017-65-4
Molecular Formula:C₃₁H₃₉NO₄S
Molecular Weight:521.721
Hs Code.:

Synonyms:(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

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Chemical Property of (R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

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Technology Process of (R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

There total 5 articles about (R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2215-77-2
4-Phenoxybenzoic acid

: 130062-64-5
methyl S-farnesylcysteine

: 1354017-65-4
(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Guidance literature:: 4-Phenoxybenzoic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

methyl S-farnesylcysteine; In N,N-dimethyl-formamide; at 0 ℃; for 2h; Inert atmosphere;

With lithium hydroxide; In methanol; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1354017-75-6
C₃₂H₄₁NO₄S

: 1354017-65-4
(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Guidance literature:: With methanol; lithium hydroxide; at 0 ℃; for 2h;
DOI:10.1016/j.bmc.2011.10.087

Reference yield:

: 6784-45-8,67023-85-2,72132-86-6,67023-84-1
(2E,6E)-farnesyl chloride

: 1354017-65-4
(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol / 0.25 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 °C

2.1: N,N-dimethyl-formamide / 2 h

3.1: methanol; lithium hydroxide / 2 h / 0 °C

With methanol; ammonia; lithium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.10.087