130062-64-5

Upstream product

• 7652-46-2 Ac-Cys-OMe 

Downstream Products

• 170892-90-7 (R)-2-({(S)-1-[(S)-2-(4-Acetoxy-benzyloxycarbonylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylsulfanyl)-propionic acid methyl ester 
• 341521-51-5 N^(α)-Fluorenylmethoxycarbonyl-N^(ε)-(4-tolyldiphenylmethyl)-(L)-lysyl-S-farnesyl-(L)-cysteine methyl ester 
• 908855-96-9 (R)-2-[2-(4-Methoxy-phenyl)-acetylamino]-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylsulfanyl)-propionic acid methyl ester 
• 908855-94-7 (R)-2-(5-Methoxy-2-nitro-benzoylamino)-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylsulfanyl)-propionic acid methyl ester 
• 908856-01-9 (R)-2-(3,5-Dinitro-benzoylamino)-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylsulfanyl)-propionic acid methyl ester 
• 908855-99-2 (R)-2-(3,5-Dichloro-benzoylamino)-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylsulfanyl)-propionic acid methyl ester 
• 774221-20-4 (R)-2-(Cyclohexanecarbonyl-amino)-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylsulfanyl)-propionic acid methyl ester 
• 908855-97-0 (R)-2-(2-Fluoro-4-methyl-benzoylamino)-3-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylsulfanyl)-propionic acid methyl ester 
• 1354017-65-4 (R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid 
• 1354017-75-6 C₃₂H₄₁NO₄S 
• 1354017-66-5 (R)-2-(3-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid 
• 1354017-76-7 C₃₂H₄₁NO₄S 
• 1354017-67-6 (R)-2-(2-benzylbenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid 
• 1354017-77-8 C₃₃H₄₃NO₃S 

Relevant academic research and scientific papers

Didehydrogeranylgeranyl (ΔΔGG): A fluorescent probe for protein prenylation

The first intrinsically fluorescent analog of geranylgeraniol, (2E,6E,8E,10E,12E,14E)-geranylgeraniol (all-trans-ΔΔGGOH·1) has been synthesized stereoselectively and shown to substitute for the geranylgeranyl (GG) moiety in prenyl transferase reactions and in protein-ligand binding assays. All-trans-ΔΔGGOH 1 showed blue fluorescence in methanol, with λex = 310 nm and λem = 410 nm (ε310 = 2.4 × 104 M-1 cm-1), but was only weakly fluorescent in aqueous solution. The prenyl transferase efficiency for ΔΔGGPP 2 as a substrate for yeast protein geranylgeranyl transferase (PGGTase-I) was 60% relative to that for GGPP. The binding of ΔΔGG-AcCysMe 3 to the recombinant Rho GTPase dissociation inhibitor (RhoGDI) had a KD of 15.1 ± 1.2 μM, 6-fold lower than the affinity of GG-AcCysMe. Thus, the ΔΔGG moiety is a novel fluorophore suitable for studying the interaction and subcellular localization of prenylated small GTPase proteins in signaling complexes. Copyright