(E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid

Base Information

Chemical Name:(E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid
CAS No.:1371574-24-1
Molecular Formula:C₂₆H₂₄O₃
Molecular Weight:384.475
Hs Code.:

Synonyms:(E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid

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Chemical Property of (E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid

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Technology Process of (E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid

There total 4 articles about (E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: ethyl [(E)-3-(4-(1-(4-methoxyphenyl)-2-phenylbut-1-enyl)phenyl)]acrylate

: 1371574-24-1
(E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; ethanol; for 24h;
DOI:10.1016/j.ejmech.2020.112191

Reference yield:

: 100-66-3
methoxybenzene

: 1371574-24-1
(E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / 2.5 h / 0 - 20 °C

2.1: magnesium; iodine / tetrahydrofuran / 4 h / 20 - 60 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

2.3: 5 h / Reflux

3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / 0 °C / Inert atmosphere

3.2: 20 h / -78 - 20 °C / Inert atmosphere

4.1: potassium hydroxide / tetrahydrofuran; ethanol / 24 h

With aluminum (III) chloride; iodine; potassium hexamethylsilazane; magnesium; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; toluene; 1.1: |Friedel-Crafts Acylation / 3.1: |Wittig-Horner Reaction / 3.2: |Wittig-Horner Reaction;
DOI:10.1016/j.ejmech.2020.112191

Reference yield:

: 78423-10-6
1-(4-methoxyphenyl)-2-phenylbutan-1-one

: 1371574-24-1
(E)-3-{4-[(E/Z)-1-(4-methoxyphenyl)-2-phenylbut-1-enyl]phenyl}acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 4 h / 20 - 60 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

1.3: 5 h / Reflux

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / 0 °C / Inert atmosphere

2.2: 20 h / -78 - 20 °C / Inert atmosphere

3.1: potassium hydroxide / tetrahydrofuran; ethanol / 24 h

With iodine; potassium hexamethylsilazane; magnesium; potassium hydroxide; In tetrahydrofuran; ethanol; toluene; 2.1: |Wittig-Horner Reaction / 2.2: |Wittig-Horner Reaction;
DOI:10.1016/j.ejmech.2020.112191