(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine

Base Information

Chemical Name:(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine
CAS No.:103795-38-6
Molecular Formula:C₁₇H₂₂N₂O₃S
Molecular Weight:334.439
Hs Code.:

Synonyms:(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine

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Chemical Property of (1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine

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Technology Process of (1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine

There total 7 articles about (1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 103795-37-5
2-[(1S,2S)-1-Azido-2-benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-thiazole

: 103795-38-6
(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Ambient temperature;

Reference yield:

: 100-39-0
benzyl bromide

: 103795-38-6
(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH; 2) nBu₄NI / 1) THf, 30 min., room temp.; 2) 3 h

3: 2) nBu₄NF / 1) CH₂Cl₂, 10 h, room temp.; 2) THF, 2 h

4: 1) MeSO₂Cl/NEt₃; 2) NaN₃ / 1) CH₂Cl₂, room temp.; 2) DMF, 80 degC

5: 82 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With lithium aluminium tetrahydride; sodium azide; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran;

Reference yield:

: 103795-12-6
(R)-2-(benzyloxy)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde

: 103795-38-6
(1S,2S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-thiazol-2-yl-ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 2) nBu₄NF / 1) CH₂Cl₂, 10 h, room temp.; 2) THF, 2 h

2: 1) MeSO₂Cl/NEt₃; 2) NaN₃ / 1) CH₂Cl₂, room temp.; 2) DMF, 80 degC

3: 82 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With lithium aluminium tetrahydride; sodium azide; tetrabutyl ammonium fluoride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran;