10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

Base Information

Chemical Name:10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester
CAS No.:215232-22-7
Molecular Formula:C₂₆H₃₀N₂O₄
Molecular Weight:434.535
Hs Code.:

Synonyms:10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

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Chemical Property of 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

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Technology Process of 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

There total 4 articles about 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: (10R,12R)-10-[1,3]Dioxolan-2-yl-12-hydroxy-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

: 215232-22-7
10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

Guidance literature:: With sodium cyanoborohydride; In acetic acid; trifluoroacetic acid; for 15h; Ambient temperature;
DOI:10.1021/jo980909o

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 215232-22-7
10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Na₂CO₃ / H₂O; tetrahydrofuran / 0 - 50 °C

2: 53 percent / NaCNBH₃ / acetic acid; trifluoroacetic acid / 15 h / Ambient temperature

With sodium cyanoborohydride; sodium carbonate; In tetrahydrofuran; water; acetic acid; trifluoroacetic acid;
DOI:10.1021/jo980909o

Reference yield:

: (2R,12bS)-2-[1,3]Dioxolan-2-yl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine

: 215232-22-7
10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Na₂CO₃ / H₂O; tetrahydrofuran / 0 - 50 °C

2: 53 percent / NaCNBH₃ / acetic acid; trifluoroacetic acid / 15 h / Ambient temperature

With sodium cyanoborohydride; sodium carbonate; In tetrahydrofuran; water; acetic acid; trifluoroacetic acid;
DOI:10.1021/jo980909o