10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

Base Information

• Chemical Name: 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester
• CAS No.: 215232-22-7
• Molecular Formula: C₂₆H₃₀N₂O₄
• Molecular Weight: 434.535
• Mol file: 215232-22-7.mol

Synonyms:10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

Chemical Property of 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

There total 4 articles about 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(10R,12R)-10-[1,3]Dioxolan-2-yl-12-hydroxy-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester → 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester (215232-22-7)

Guidance literature:

With sodium cyanoborohydride; In acetic acid; trifluoroacetic acid; for 15h; Ambient temperature;

DOI:10.1021/jo980909o

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester (215232-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / Na₂CO₃ / H₂O; tetrahydrofuran / 0 - 50 °C

2: 53 percent / NaCNBH₃ / acetic acid; trifluoroacetic acid / 15 h / Ambient temperature

With sodium cyanoborohydride; sodium carbonate; In tetrahydrofuran; water; acetic acid; trifluoroacetic acid;

DOI:10.1021/jo980909o

Reference yield:

(2R,12bS)-2-[1,3]Dioxolan-2-yl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine → 10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester (215232-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / Na₂CO₃ / H₂O; tetrahydrofuran / 0 - 50 °C

2: 53 percent / NaCNBH₃ / acetic acid; trifluoroacetic acid / 15 h / Ambient temperature

With sodium cyanoborohydride; sodium carbonate; In tetrahydrofuran; water; acetic acid; trifluoroacetic acid;

DOI:10.1021/jo980909o

upstream raw materials:

benzyl chloroformate

Downstream raw materials:

10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester