10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester

Base Information

Chemical Name:10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester
CAS No.:215232-23-8
Molecular Formula:C₂₈H₃₂N₂O₆
Molecular Weight:492.572
Hs Code.:

Synonyms:10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester

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Chemical Property of 10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester

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Technology Process of 10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester

There total 4 articles about 10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 17640-15-2
methyl cyanoformate

: 215232-22-7
10-[1,3]Dioxolan-2-yl-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid benzyl ester

: 215232-23-8
10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; cyclohexane; at -78 - 20 ℃;
DOI:10.1021/jo980909o

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 215232-23-8
10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / Na₂CO₃ / H₂O; tetrahydrofuran / 0 - 50 °C

2: 53 percent / NaCNBH₃ / acetic acid; trifluoroacetic acid / 15 h / Ambient temperature

3: 95 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide; cyclohexane / -78 - 20 °C

With sodium cyanoborohydride; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; cyclohexane; water; acetic acid; trifluoroacetic acid;
DOI:10.1021/jo980909o

Reference yield:

: (2R,12bS)-2-[1,3]Dioxolan-2-yl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine

: 215232-23-8
10-[1,3]Dioxolan-2-yl-5,8,9,10,11,12-hexahydro-6H-7,13-diaza-cyclodeca[a]indene-7,13-dicarboxylic acid 7-benzyl ester 13-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / Na₂CO₃ / H₂O; tetrahydrofuran / 0 - 50 °C

2: 53 percent / NaCNBH₃ / acetic acid; trifluoroacetic acid / 15 h / Ambient temperature

3: 95 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide; cyclohexane / -78 - 20 °C

With sodium cyanoborohydride; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; cyclohexane; water; acetic acid; trifluoroacetic acid;
DOI:10.1021/jo980909o