N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide
CAS No.:950481-62-6
Molecular Formula:C₂₃H₁₆ClF₉N₂O₂
Molecular Weight:558.831
Hs Code.:

Synonyms:N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide

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Chemical Property of N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide

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Technology Process of N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide

There total 5 articles about N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[(2-chloro-4-chlorohydroxyiminomethylphenyl)methyl] cyclopropanecarboxamide

: 329-42-0
1,3-bis(trifluoromethyl)-5-(1,1,1-trifluoroprop-2-en-2-yl)benzene

: 950481-62-6
N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide

Guidance literature:: With potassium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 20 ℃; for 15h;

Reference yield:

: 135049-84-2
4-bromomethyl-3-chloroiodobenzene

: 950481-62-6
N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: N,N-dimethyl-formamide / 1 h / 20 °C

2: hydrazine / ethanol; water / 0.5 h / 70 °C

3: triethylamine / chloroform / 1 h / 0 - 20 °C

4: sodium formate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 90 °C / 11251.1 Torr

5: hydroxylamine hydrochloride / methanol; water / 1 h / 20 °C

6: N-chloro-succinimide / 1,2-dimethoxyethane / 1.5 h / 70 °C

7: potassium hydrogencarbonate / 1,2-dimethoxyethane; water / 15 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium formate; potassium hydrogencarbonate; triethylamine; hydrazine; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 950482-88-9
2-chloro-4-iodobenzylamine

: 950481-62-6
N-[2-chloro-4-[5-[3,5-bis(trifluoromethyl)phenyl]-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenylmethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / chloroform / 1 h / 0 - 20 °C

2: sodium formate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 90 °C / 11251.1 Torr

3: hydroxylamine hydrochloride / methanol; water / 1 h / 20 °C

4: N-chloro-succinimide / 1,2-dimethoxyethane / 1.5 h / 70 °C

5: potassium hydrogencarbonate / 1,2-dimethoxyethane; water / 15 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium formate; potassium hydrogencarbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide;