N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Base Information

Chemical Name:N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide
CAS No.:1567351-20-5
Molecular Formula:C₃₅H₄₁N₃O₅
Molecular Weight:583.728
Hs Code.:

Synonyms:N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

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Chemical Property of N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

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Technology Process of N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

There total 11 articles about N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 106-52-5
N-methyl-4-hydroxypiperidine

: 1567350-51-9
N-(2-butoxy-7-hydroxy-8-methylquinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

: 1567351-20-5
N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2013.12.056

Reference yield:

: 154521-00-3
7-hydroxy-8-methylquinolin-2(1H)-one

: 1567351-20-5
N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

3: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

4: trimethylsilylazide; ethanolamine / N,N-dimethyl acetamide / 6 h / 95 °C / Sealed tube

5: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C

6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h

7: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

With pyridine; N-Bromosuccinimide; trimethylsilylazide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; ethanolamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide; 7: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.12.056

Reference yield:

: 1567348-80-4
7-(benzyloxy)-8-methylquinolin-2(1H)-one

: 1567351-20-5
N-(2-butoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

2: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

3: trimethylsilylazide; ethanolamine / N,N-dimethyl acetamide / 6 h / 95 °C / Sealed tube

4: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

With pyridine; N-Bromosuccinimide; trimethylsilylazide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; ethanolamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide; 6: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.12.056