cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene

Base Information

• Chemical Name: cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene
• CAS No.: 99749-12-9
• Molecular Formula: C₁₈H₁₄F₆O₂
• Molecular Weight: 376.298
• Mol file: 99749-12-9.mol

Synonyms:cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene

Chemical Property of cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene

There total 2 articles about cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone (30724-22-2) → cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene (99749-12-9) + trans-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene (99749-11-8)

Guidance literature:

With pyridine; titanium tetrachloride; zinc; In 1,4-dioxane; at 101 ℃; for 4h;

DOI:10.1021/jm00153a004

Reference yield:

(3-methoxyphenyl)magnesium bromide (36282-40-3) → cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene (99749-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / diethyl ether / 2 h / Heating

2: 22 percent / TiCl₄, Zn, pyridine / dioxane / 4 h / 101 °C

With pyridine; titanium tetrachloride; zinc; In 1,4-dioxane; diethyl ether;

DOI:10.1021/jm00153a004

Reference yield: 87.0%

cis-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)but-2-ene (99749-12-9) → meso-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)butane (99749-14-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00153a004

upstream raw materials:

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone

(3-methoxyphenyl)magnesium bromide

Downstream raw materials:

meso-1,1,1,4,4,4-hexafluoro-2,3-bis(3-methoxyphenyl)butane

meso-1,1,1,4,4,4-hexafluoro-2,3-bis(3-hydroxyphenyl)butane