(3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

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Chemical Name:(3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene
CAS No.:596792-52-8
Molecular Formula:C₄₇H₇₀O₇Si₂
Molecular Weight:803.24
Hs Code.:

(3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

Synonyms:(3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

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Chemical Property of (3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

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Technology Process of (3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

There total 5 articles about (3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 596792-67-5
(3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-ol

: 596792-52-8
(3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

Guidance literature:: With 2,6-dimethylpyridine; In 1,2-dichloro-ethane; at 50 ℃;
DOI:10.1016/S0040-4039(03)01214-0

Reference yield:

: 474125-28-5
(2R,4aR,6S,7R,9S,10aS)-6-Hydroxymethyl-2-(4-methoxy-phenyl)-9-methyl-octahydro-1,3,5-trioxa-benzocycloocten-7-ol

: 596792-52-8
(3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.42 h / -78 °C

1.2: CH₂Cl₂ / 0.5 h / -78 °C

2.1: n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 0.67 h / -100 °C

3.1: 7.36 g / p-TsOH*H₂O; p-methoxybenzaldehyde dimethyl acetal / CHCl₃ / 2 h / 40 °C

4.1: 100 percent / NaBH₄ / CH₂Cl₂; methanol / 0.67 h / -78 °C

5.1: 100 percent / 2,6-lutidine / 1,2-dichloro-ethane / 3.33 h / 50 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; n-butyllithium; p-Anisaldehyde dimethyl acetal; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; chloroform; 1,2-dichloro-ethane;
DOI:10.1021/jo049877x

Reference yield:

: 596792-51-7
(3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

: 596792-52-8
(3R,4aS,6S,7aR,9S,10R,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-10-triisopropylsilanyloxy-decahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cyclooctene

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaBH₄ / CH₂Cl₂; methanol / 0.67 h / -78 °C

2: 100 percent / 2,6-lutidine / 1,2-dichloro-ethane / 3.33 h / 50 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo049877x