(3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

Base Information

Chemical Name:(3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one
CAS No.:596792-51-7
Molecular Formula:C₃₈H₄₈O₇Si
Molecular Weight:644.88
Hs Code.:

(3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

Synonyms:(3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

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Chemical Property of (3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

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Technology Process of (3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

There total 3 articles about (3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 596792-50-6
(2R,4aR,6S,7R,9R,10aS)-6-[(2S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-2-(toluene-4-sulfonyl)-oxiranylmethyl]-2-(4-methoxy-phenyl)-9-methyl-7-triethylsilanyloxy-octahydro-1,3,5-trioxa-benzocyclooctene

: 596792-51-7
(3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

Guidance literature:: With p-Anisaldehyde dimethyl acetal; toluene-4-sulfonic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0040-4039(03)01214-0

Reference yield:

: 474125-28-5
(2R,4aR,6S,7R,9S,10aS)-6-Hydroxymethyl-2-(4-methoxy-phenyl)-9-methyl-octahydro-1,3,5-trioxa-benzocycloocten-7-ol

: 596792-51-7
(3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.42 h / -78 °C

1.2: CH₂Cl₂ / 0.5 h / -78 °C

2.1: n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 0.67 h / -100 °C

3.1: 7.36 g / p-TsOH*H₂O; p-methoxybenzaldehyde dimethyl acetal / CHCl₃ / 2 h / 40 °C

With 2,6-dimethylpyridine; n-butyllithium; p-Anisaldehyde dimethyl acetal; toluene-4-sulfonic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; chloroform;
DOI:10.1021/jo049877x

Reference yield:

: Trifluoro-methanesulfonic acid (2R,4aR,6S,7R,9R,10aS)-2-(4-methoxy-phenyl)-9-methyl-7-triethylsilanyloxy-octahydro-1,3,5-trioxa-benzocycloocten-6-ylmethyl ester

: 596792-51-7
(3R,4aS,6S,7aR,9S,11aS,12aR)-9-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-phenyl)-6,9-dimethyl-octahydro-2,4,8,12-tetraoxa-dibenzo[a,d]cycloocten-10-one

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 0.67 h / -100 °C

2: 7.36 g / p-TsOH*H₂O; p-methoxybenzaldehyde dimethyl acetal / CHCl₃ / 2 h / 40 °C

With n-butyllithium; p-Anisaldehyde dimethyl acetal; toluene-4-sulfonic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; chloroform;
DOI:10.1021/jo049877x