2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

Base Information

Chemical Name:2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile
CAS No.:1360056-29-6
Molecular Formula:C₁₆H₁₉FN₂O
Molecular Weight:274.338
Hs Code.:

Synonyms:2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

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Chemical Property of 2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

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Technology Process of 2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

There total 5 articles about 2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 78-82-0
Isobutyronitrile

: 1360056-28-5
2-(2,4-difluoro-6-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

: 1360056-29-6
2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -20 - 15 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1360056-26-3
2,4,6-trifluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)benzamide

: 1360056-29-6
2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 20 °C / Cooling with ice bath

2: diethyl ether; tetrahydrofuran / 0 - 20 °C

3: potassium hexamethylsilazane / toluene; tetrahydrofuran / -20 - 15 °C / Inert atmosphere

With thionyl chloride; potassium hexamethylsilazane; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;

Reference yield:

: 28314-80-9
2,4,6-trifluorobenzoic acid

: 1360056-29-6
2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0 - 20 °C

2: thionyl chloride / dichloromethane / 20 °C / Cooling with ice bath

3: diethyl ether; tetrahydrofuran / 0 - 20 °C

4: potassium hexamethylsilazane / toluene; tetrahydrofuran / -20 - 15 °C / Inert atmosphere

With thionyl chloride; potassium hexamethylsilazane; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;