4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide

Base Information

• Chemical Name: 4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide
• CAS No.: 1027721-48-7
• Molecular Formula: C₂₇H₂₉N₅O₄S
• Molecular Weight: 519.624
• Mol file: 1027721-48-7.mol

Synonyms:4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide

Chemical Property of 4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide

There total 5 articles about 4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Naphthalenesulfonyl chloride (93-11-8) → 4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide (1027721-48-7)

Guidance literature:

Multi-step reaction with 4 steps

1: N-methylmorpholine / dioxane; ethyl acetate / 16 h / Ambient temperature

2: 1N aq. HCl, AcOH / 2 h / Heating

3: SOCl₂ / 1 h / Heating

4: tetrahydrofuran / 1 h

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

DOI:10.1021/jm960668h

Reference yield:

Nα-(2-naphthylsulfonyl)-3-cyano-D-phenylalanine → 4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide (1027721-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: tetrahydrofuran / 1 h

With thionyl chloride; In tetrahydrofuran;

DOI:10.1021/jm960668h

Reference yield:

Nα-(2-naphthylsulfonyl)-3-cyano-D-phenylalanine methyl ester → 4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide (1027721-48-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1N aq. HCl, AcOH / 2 h / Heating

2: SOCl₂ / 1 h / Heating

3: tetrahydrofuran / 1 h

With hydrogenchloride; thionyl chloride; acetic acid; In tetrahydrofuran;

DOI:10.1021/jm960668h

upstream raw materials:

piperazine-1-carboxylic acid dimethylamide

2-Naphthalenesulfonyl chloride