n,n-Dimethylpiperazine-1-carboxamide

Base Information

• Chemical Name: n,n-Dimethylpiperazine-1-carboxamide
• CAS No.: 41340-78-7
• Molecular Formula: C7H15N3O
• Molecular Weight: 157.216
• Hs Code.: 2933599090
• European Community (EC) Number: 674-590-9
• DSSTox Substance ID: DTXSID50351897
• Wikidata: Q82128718
• ChEMBL ID: CHEMBL1616670
• Mol file: 41340-78-7.mol

Synonyms:n,n-dimethylpiperazine-1-carboxamide;41340-78-7;Piperazine-1-carboxylic acid dimethylamide;N,N-dimethyl-1-piperazinecarboxamide;MFCD01050443;piperazine-1-carboxylic acid dimethyl amide;1-Piperazinecarboxamide, N,N-dimethyl-;SCHEMBL6112;TimTec1_006312;CHEMBL1616670;DTXSID50351897;HMS1551O20;4-(dimethylaminocarbonyl)piperazine;AMY36352;BCP18682;STK524302;AKOS000147494;AKOS002245260;N,N-dimethyl 1-piperazine carboxamide;piperazine carboxylic acid dimethylamide;PS-3234;NN-DIMETHYLPIPERAZINE-1-CARBOXAMIDE;Piperazine-1-carboxylic acid, dimethylamide;CS-0151344;FT-0693677;EN300-36878;PIPERAZINE-1-CARBOXYLICACIDDIMETHYLAMIDE;A825523;piperazine-1-carboxylic acid dimethylamide, AldrichCPR;Z270760338

Chemical Property of n,n-Dimethylpiperazine-1-carboxamide

Chemical Property:

• Vapor Pressure: 0.00586mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 273.1 °C at 760 mmHg
• PKA: 8.55±0.10(Predicted)
• Flash Point: 118.9 °C
• PSA: 35.58000
• Density: 1.058 g/cm³
• LogP: -0.16010
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 157.121512110
• Heavy Atom Count: 11
• Complexity: 141

Purity/Quality:

97% ^*data from raw suppliers

N,N-Dimethylpiperazine-1-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-22
• Safety Statements: 26-24/25-23

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C(=O)N1CCNCC1

Technology Process of n,n-Dimethylpiperazine-1-carboxamide

There total 3 articles about n,n-Dimethylpiperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

piperazine (110-85-0) + N,N-Dimethylcarbamoyl chloride (79-44-7) → piperazine-1-carboxylic acid dimethylamide (41340-78-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

Reference yield:

tert-butyl 4-(dimethylcarbamoyl)piperazine-1-carboxylate (215453-81-9) → piperazine-1-carboxylic acid dimethylamide (41340-78-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 3h;

Reference yield:

→ piperazine-1-carboxylic acid dimethylamide (41340-78-7)

Guidance literature:

upstream raw materials:

piperazine

N,N-Dimethylcarbamoyl chloride

tert-butyl 4-(dimethylcarbamoyl)piperazine-1-carboxylate

Downstream raw materials:

4-[(R)-3-(3-Cyano-phenyl)-2-(naphthalene-2-sulfonylamino)-propionyl]-piperazine-1-carboxylic acid dimethylamide

4-[7-(4-formylphenyl)-6-phenylpyrido[2,3-d]pyrimidin-2-yl]-N,N-dimethylpiperazine-1-carboxamide

4-[(2E)-4-{4-[(3,4-dichlorophenyl)amino]-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-7(6H)-yl}-4-oxobut-2-en-1-yl]-N,N-dimethylpiperazine-1-carboxamide

4-[6-(4-hydroxy-phenyl)-3-((E)-styryl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-piperazine-1-carboxylic acid dimethylamide