(2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate

Base Information

Chemical Name:(2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate
CAS No.:1414547-42-4
Molecular Formula:C₁₉H₁₈N₂O₅S
Molecular Weight:386.428
Hs Code.:

Synonyms:(2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate

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Chemical Property of (2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate

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Technology Process of (2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate

There total 3 articles about (2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1414547-40-2
(E)-ethyl 2-(2-benzamido-3-(methylthio)-3-(thiophen-2-yl)acrylamido)-3-hydroxypropanoate

: 1414547-42-4
(2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;
DOI:10.1021/jo3021192

Reference yield:

: 4117-31-1
ethyl L-serinate

: 1414547-42-4
(2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / ethanol / Reflux

2: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo3021192

Reference yield:

: 1236209-08-7
4-(methylthio(thiophen-2-yl)methylene)-2-phenyloxazol-5(4H)-one

: 1414547-42-4
(2S)-ethyl 3-hydroxy-2-[2-phenyl-5-(thiophen-2-yl)oxazole-4-carboxamido]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / ethanol / Reflux

2: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo3021192