2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate

Base Information

• Chemical Name: 2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate
• CAS No.: 1071467-53-2
• Molecular Formula: C₂₉H₃₇NO₈S
• Molecular Weight: 559.681
• Mol file: 1071467-53-2.mol

Synonyms:2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate

Chemical Property of 2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate

There total 13 articles about 2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl 4-(6-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)naphthalen-2-yl)phenyl(methyl)carbamate (1071467-51-0) + methanesulfonyl chloride (124-63-0) → 2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate (1071467-53-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

(6-((tert-butyldimethylsilyl)oxy)naphthalen-2-yl)boronic acid (179942-45-1) → 2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate (1071467-53-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 100 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 160 °C / microwave irradiation

4.1: hydrogenchloride; tin(ll) chloride / ethanol / 2 h / Heating / reflux

5.1: sodium methylate / methanol / 1.5 h / Heating / reflux

5.2: 1.5 h / 0 °C / Heating / reflux

6.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

7.1: tetrahydrofuran / Heating / reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

9.1: triethylamine / dichloromethane / 20 °C

With 1H-imidazole; hydrogenchloride; tetrabutyl ammonium fluoride; water; sodium methylate; sodium carbonate; potassium carbonate; triethylamine; tin(ll) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

6-bromo-naphthalen-2-ol (15231-91-1) → 2-(2-(2-(6-(4-(tert-butoxycarbonyl(methyl)amino)phenyl)naphthalen-2-yloxy)ethoxy)ethoxy)ethyl methanesulfonate (1071467-53-2)

Guidance literature:

Multi-step reaction with 13 steps

1.1: 1H-imidazole / dichloromethane / 2 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.83 h / -78 °C

3.1: tetrahydrofuran / 0.33 h / -78 - 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / Acidic conditions

5.1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 100 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 160 °C / microwave irradiation

8.1: hydrogenchloride; tin(ll) chloride / ethanol / 2 h / Heating / reflux

9.1: sodium methylate / methanol / 1.5 h / Heating / reflux

9.2: 1.5 h / 0 °C / Heating / reflux

10.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

11.1: tetrahydrofuran / Heating / reflux

12.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

13.1: triethylamine / dichloromethane / 20 °C

With 1H-imidazole; hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium methylate; sodium carbonate; potassium carbonate; triethylamine; tin(ll) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

tert-butyl 4-(6-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)naphthalen-2-yl)phenyl(methyl)carbamate

methanesulfonyl chloride

(6-((tert-butyldimethylsilyl)oxy)naphthalen-2-yl)boronic acid

6-bromo-naphthalen-2-ol

Downstream raw materials:

[18F] [4-(6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}naphthalen-2-yl)phenyl]methylamine