(+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine

Base Information

• Chemical Name: (+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine
• CAS No.: 889885-73-8
• Molecular Formula: C₅₆H₆₀N₅O₇P
• Molecular Weight: 946.095

Synonyms:(+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property of (+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property:

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Technology Process of (+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine

There total 1 articles about (+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(+/-)-9-[(1-hydroxymethyl)(3-(4-monomethoxytrityl)oxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-26-1) + bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate (35717-98-7) → (+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N6-(4-monomethoxytrityl)-adenine (889885-73-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1080/15257770500265315

Reference yield: 47.0%

(+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N6-(4-monomethoxytrityl)-adenine (889885-73-8) → (+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytrityloxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-88-5)

Guidance literature:

With trimethylsilyl iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1080/15257770500265315

Reference yield: 17.0%

(+/-)-9-[1-[(diisopropylphosphono)methoxymethyl](3-(4-monomethoxytrityl)oxy)-propyl]-N6-(4-monomethoxytrityl)-adenine (889885-73-8) → (+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-hydroxy)-propyl]-N6-(4-monomethoxytrityl)-adenine (889885-74-9)

Guidance literature:

With hydrogenchloride; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1080/15257770500265315

upstream raw materials:

(+/-)-9-[(1-hydroxymethyl)(3-(4-monomethoxytrityl)oxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

Downstream raw materials:

(+/-)-9-[1-[(diisopropylphosphono)methoxy]methyl][(3-hydroxy)-propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-(phosphonomethoxy)methyl][3-(4-monomethoxytrityloxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

(+/-)-9-[1-[(phosphonomethoxy)methyl](3-methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

[4-azido-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-butoxymethyl]-phosphonic acid

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