C₂₈H₁₈N₆

Base Information

• Chemical Name: C₂₈H₁₈N₆
• CAS No.: 1431571-91-3
• Molecular Formula: C₂₈H₁₈N₆
• Molecular Weight: 438.491
• Mol file: 1431571-91-3.mol

Synonyms:C₂₈H₁₈N₆

Chemical Property of C₂₈H₁₈N₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₈H₁₈N₆

There total 5 articles about C₂₈H₁₈N₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C20H12N6 (1431571-90-2) + phenylacetylene (536-74-3) → C28H18N6 (1431571-91-3)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1039/c3cc41209a

Reference yield:

2,6-dibromo-4-(hydroxymethyl)pyridine (223463-02-3) → C28H18N6 (1431571-91-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / toluene / 24 h / 20 °C / Inert atmosphere; Darkness

1.2: 24 h / 20 °C / Inert atmosphere

2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 20 °C / Inert atmosphere; Darkness

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C

4.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / N,N-dimethyl-formamide; water / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; carbon tetrabromide; sodium L-ascorbate; triethylamine; triphenylphosphine; In dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1039/c3cc41209a

Reference yield:

C20H13N3O (1431571-88-8) → C28H18N6 (1431571-91-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 20 °C / Inert atmosphere; Darkness

2: sodium azide / N,N-dimethyl-formamide / 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / N,N-dimethyl-formamide; water / 16 h / 20 °C

With sodium azide; copper(ll) sulfate pentahydrate; carbon tetrabromide; sodium L-ascorbate; triphenylphosphine; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1039/c3cc41209a

upstream raw materials:

C₂₀H₁₂N₆

phenylacetylene

2,6-dibromo-4-(hydroxymethyl)pyridine

C₂₀H₁₃N₃O