2-Amino-4-cyanopyridine

Base Information

• Chemical Name: 2-Amino-4-cyanopyridine
• CAS No.: 223463-02-3
• Molecular Formula: C₆H₅Br₂NO
• Molecular Weight: 266.92
• Mol file: 223463-02-3.mol

Synonyms:(2,6-Dibromopyridin-4-yl)methanol

Chemical Property of 2-Amino-4-cyanopyridine

Chemical Property:

• Melting Point: 110.0-111.5 °C
• Boiling Point: 379.7±37.0 °C(Predicted)
• PKA: 12.67±0.10(Predicted)
• PSA: 33.12000
• Density: 2.071±0.06 g/cm3(Predicted)
• LogP: 2.09890
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dibromo-4-hydroxymethylpyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4-cyanopyridine

There total 8 articles about 2-Amino-4-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C6H2Br3NO → 2,6-dibromo-4-(hydroxymethyl)pyridine (223463-02-3)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/om100131t

Reference yield: 98.0%

2,6-dibromoisonicotinic acid (2016-99-1) → 2,6-dibromo-4-(hydroxymethyl)pyridine (223463-02-3)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 50 ℃; for 0.166667h;

Reference yield: 91.0%

methyl 2,6-dibromoisonicotinate (119308-57-5) → 2,6-dibromo-4-(hydroxymethyl)pyridine (223463-02-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 65 ℃; for 3h;

DOI:10.1021/acs.jmedchem.9b02061

upstream raw materials:

C-(2,6-dibromo-[4]pyridyl)-methylamine

methyl 2,6-dibromoisonicotinate

ethyl 2,6-dibromo-pyridine-4-carboxylate

2,6-dibromoisonicotinic acid

Downstream raw materials:

2,6-Dibromopyridine-4-carbaldehyde

4′-formyl-2,2′:6′2″-terpyridine

C₂₈H₁₈N₆

2,2':6,2''-terpyridine