N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Base Information

Chemical Name:N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide
CAS No.:1387561-21-8
Molecular Formula:C₁₈H₁₆BrF₃N₄O₅S
Molecular Weight:537.314
Hs Code.:

Synonyms:N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

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Chemical Property of N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

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Technology Process of N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

There total 3 articles about N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1387561-19-4
2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

: 1387561-21-8
N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Guidance literature:: With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 18.5h;

Reference yield:

: 1387560-89-5
2-bromo-5-fluoro-4-[2-methyl-1-(2-nitrobenzenesulfonyl)aziridin-2-yl]pyridine

: 1387561-21-8
N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.67 h / 20 °C / 4? molecular sieves

2: triethylamine; trifluoroacetic anhydride / dichloromethane / 18.5 h / 0 - 20 °C

With sodium hydride; triethylamine; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1387560-90-8
2-bromo-5-fluoro-4-(2-methylaziridin-2-yl)pyridine

: 1387561-21-8
N-[1-(2-bromo-5-fluoro-pyridin-4-yl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; aluminum oxide / water; tetrahydrofuran / 1.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.67 h / 20 °C / 4? molecular sieves

3: triethylamine; trifluoroacetic anhydride / dichloromethane / 18.5 h / 0 - 20 °C

With 4-methyl-morpholine; aluminum oxide; sodium hydride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;