2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

Base Information

Chemical Name:2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester
CAS No.:1387561-19-4
Molecular Formula:C₂₀H₂₁BrF₃N₃O₇S
Molecular Weight:584.368
Hs Code.:

Synonyms:2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

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Chemical Property of 2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

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Technology Process of 2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

There total 3 articles about 2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1386985-78-9
ethyl 3-fluoro-2-(fluoromethyl)-2-hydroxypropanoate

: 1387560-89-5
2-bromo-5-fluoro-4-[2-methyl-1-(2-nitrobenzenesulfonyl)aziridin-2-yl]pyridine

: 1387561-19-4
2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3.66667h; 4? molecular sieves;

Reference yield:

: 1387560-90-8
2-bromo-5-fluoro-4-(2-methylaziridin-2-yl)pyridine

: 1387561-19-4
2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; aluminum oxide / water; tetrahydrofuran / 1.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.67 h / 20 °C / 4? molecular sieves

With 4-methyl-morpholine; aluminum oxide; sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 41404-58-4
2-bromo-5-fluoropyridine

: 1387561-19-4
2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: lithium diisopropyl amide / tetrahydrofuran; acetone / 2 h / -78 °C / Inert atmosphere

2: triethylamine; Methanesulfonic anhydride / dichloromethane / 40 h / 20 °C

3: osmium(VIII) oxide / water; acetone / 17 h / 20 °C

4: triethylamine / dichloromethane / 0.67 h / 0 °C

5: sodium azide; ammonium chloride / ethanol / 20 h / 80 °C

6: triethylamine / dichloromethane / 2 h / 0 - 20 °C

7: triphenylphosphine; citric acid / water; tert-butyl methyl ether; tetrahydrofuran / 0.5 h / 20 °C

8: 4-methyl-morpholine; aluminum oxide / water; tetrahydrofuran / 1.5 h / 20 °C

9: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.67 h / 20 °C / 4? molecular sieves

With 4-methyl-morpholine; aluminum oxide; osmium(VIII) oxide; sodium azide; sodium hydride; ammonium chloride; triethylamine; triphenylphosphine; citric acid; lithium diisopropyl amide; Methanesulfonic anhydride; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; acetone; mineral oil;