Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester
CAS No.:98264-10-9
Molecular Formula:C₃₅H₃₈N₆O₁₀
Molecular Weight:702.721
Hs Code.:

Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester

Synonyms:Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester

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Chemical Property of Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester

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Technology Process of Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester

There total 2 articles about Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90742-12-4
2',3',5'-tri-O-propionyl-N²-propionylguanosine

: 83-01-2
diphenylcarbamic chloride

: 98264-10-9
Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: With bis(triphenyltin) oxide; Yield given. Multistep reaction; 1) benzene, reflux, 15 min, 2) pyridine, r.t., 30 min;
DOI:10.1016/S0040-4039(00)84907-2

Reference yield:

: 118-00-3
G

: 98264-10-9
Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / DMAP / pyridine / 3 h / 70 °C

2: i-Pr₂NEt / pyridine / 1 h / Ambient temperature

With dmap; N-ethyl-N,N-diisopropylamine; In pyridine;
DOI:10.1021/ja00328a042

Reference yield:

: 98264-10-9
Propionic acid (2R,3R,4R,5R)-2-(6-diphenylcarbamoyloxy-2-propionylamino-purin-9-yl)-4-propionyloxy-5-propionyloxymethyl-tetrahydro-furan-3-yl ester

: 117-68-0
Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(hydroxy-phenylsulfanyl-phosphoryloxy)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 2M NaOH / pyridine; ethanol / 0 °C

2: 90 percent / pyridine / 2 h

3: TFA / CH₂Cl₂ / 11 h

4: KF, Et₄NBr H₂O / acetonitrile / 0.75 h / 50 °C

5: 94 percent / pyridine / 0.5 h

6: 91 percent / pyridine, MDS / 5.5 h

7: 1.5 M pyridinium phosphinate/pyridine, Et₃N / 0.5 h / 40 °C

With pyridine; potassium fluoride; sodium hydroxide; H₂O₂P*C₅H₅N; tetraethylammonium bromide; triethylamine; trifluoroacetic acid; In pyridine; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ja00328a042