Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

Base Information

Chemical Name:Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester
CAS No.:98889-41-9
Molecular Formula:C₄₃H₄₃N₆O₉PS₂
Molecular Weight:882.955
Hs Code.:

Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

Synonyms:Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

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Chemical Property of Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

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Technology Process of Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

There total 11 articles about Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 90762-77-9
S,S-diphenyl 2'-O-(tetrahydropyran-2-yl)-5'-O-(4,4'-dimethoxytrityl)-O⁶-(diphenylcarbamoyl)-N²-propionylguanosine-3'-phosphorodithioate

: 98889-41-9
Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

Guidance literature:: With zinc dibromide; In dichloromethane; isopropyl alcohol; at 0 ℃; for 0.05h;
DOI:10.1021/ja00328a042

Reference yield: 93.0%

: 102633-24-9
C₉₀H₆₃Cl₆N₈O₁₃PS₂

: 98889-41-9
Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

Guidance literature:: With hydrazine hydrate; In pyridine; acetic acid; for 0.333333h; Ambient temperature;
DOI:10.1021/ja00275a052

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 98889-41-9
Diphenyl-carbamic acid 9-[(2R,3R,4R,5R)-4-(bis-phenylsulfanyl-phosphoryloxy)-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-propionylamino-9H-purin-6-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: TFA / CH₂Cl₂ / 11 h

2: KF, Et₄NBr H₂O / acetonitrile / 0.75 h / 50 °C

3: 94 percent / pyridine / 0.5 h

4: 91 percent / pyridine, MDS / 5.5 h

5: 99 percent / 0.5 M ZnBr₂ / CH₂Cl₂; propan-2-ol / 0.05 h / 0 °C

With pyridine; potassium fluoride; tetraethylammonium bromide; trifluoroacetic acid; zinc dibromide; In dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/ja00328a042