N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide

Base Information

Chemical Name:N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide
CAS No.:765269-10-1
Molecular Formula:C₂₆H₂₉N₃O₂S
Molecular Weight:447.601
Hs Code.:

Synonyms:N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide

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Chemical Property of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide

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Technology Process of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide

There total 9 articles about N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide

: 765269-10-1
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-dioxane; water

2: potassium acetate; sodium carbonate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 36 h / 60 - 90 °C

3: hydrogenchloride / water; acetonitrile

With hydrogenchloride; potassium acetate; sodium carbonate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); water; acetonitrile;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzothiophene-2-carboxamide hydrochloride

: 765269-10-1
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; sodium carbonate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 36 h / 60 - 90 °C

2: hydrogenchloride / water; acetonitrile

With hydrogenchloride; potassium acetate; sodium carbonate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); water; acetonitrile;

Reference yield:

: 149947-15-9
3-bromo-2-fluorobenzaldehyde

: 765269-10-1
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[ethyl(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride

2: 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetratetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide)

3: 1,4-dioxane; water

4: potassium acetate; sodium carbonate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 36 h / 60 - 90 °C

5: hydrogenchloride / water; acetonitrile

With hydrogenchloride; 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetratetramethyluronium hexafluorophosphate; potassium acetate; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); water; acetonitrile;