149947-15-9Relevant articles and documents
Enantioselective Total Synthesis of Beraprost Using Organocatalyst
Umemiya, Shigenobu,Sakamoto, Daisuke,Kawauchi, Genki,Hayashi, Yujiro
, p. 1112 - 1115 (2017)
A convergent and enantioselective total synthesis of the most active isomer of beraprost was achieved in 17 pots. A unique tricyclic core in beraprost was synthesized efficiently by utilizing the asymmetric organocatalyst-mediated formal [3 + 2] cycloaddi
N-(piperidin-4-yl)benzo[b]thiophenecarboxamide derivatives, preparation method therof, and pharmaceutical composition for use in preventing or treating Urotensin-Ⅱ receptor activity related diseases containing the same as an active ingredient
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Paragraph 0181; 0182; 0183; 0184, (2016/10/10)
The present invention relates to N-(piperidin-4-yl)benzo[b]thiophenecarboxamide derivatives, a manufacturing method thereof, and a pharmaceutical composition for preventing or treating urotensin-II receptor activity-related diseases comprising the same as an active ingredient. The N-(piperidin-4-yl)benzo[b]thiophenecarboxamide derivatives can be usefully used for preventing or treating urotensin-II receptor activity-related diseases such as congestive heart failure, ischemic heart, myocardial infarction, cardiomegaly, fibrosis cordis, coronary artery disease, arteriosclerosis, hypertension, asthma, renal failure, diabetes, vasculitis, neurodegenerative disease, stroke, pain, depressive disorder, psychosis, cancer, etc., by acting as an antagonist with respect to a urotensin-II receptor.COPYRIGHT KIPO 2016
SULPHONYLAMINOPYRROLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
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Page/Page column 42; 43, (2013/07/05)
The invention relates to new sulphonylaminopyrrolidinone compounds having antithrombotic activity which, in particular, inhibit blood clotting factor IXa and/ or factor Xa, to processes for their preparation and to use thereof as drugs.