Technology Process of benzyl (3-[1-methyl-2-oxo-(1H)-pyridinyl])-methyl ether
There total 4 articles about benzyl (3-[1-methyl-2-oxo-(1H)-pyridinyl])-methyl ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride;
In
dichloromethane;
at 20 ℃;
for 24h;
DOI:10.1021/jo9918394
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 96 percent / KOH / methanol; H2O / 2 h / Heating
2.1: SOCl2 / 1 h / Heating
2.2: 92 percent / 0.5 h / Heating
3.1: 47 percent / diisobutylaluminum hydride / tetrahydrofuran / 3 h / 0 °C
4.1: 50 percent / aq. NaOH; benzyltriethylammonium chloride / CH2Cl2 / 24 h / 20 °C
With
potassium hydroxide; sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; diisobutylaluminium hydride;
In
tetrahydrofuran; methanol; dichloromethane; water;
1.1: Methylation / 2.1: Substitution / 2.2: Substitution / 3.1: Reduction / 4.1: Alkylation;
DOI:10.1021/jo9918394
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: SOCl2 / 1 h / Heating
1.2: 92 percent / 0.5 h / Heating
2.1: 47 percent / diisobutylaluminum hydride / tetrahydrofuran / 3 h / 0 °C
3.1: 50 percent / aq. NaOH; benzyltriethylammonium chloride / CH2Cl2 / 24 h / 20 °C
With
sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; diisobutylaluminium hydride;
In
tetrahydrofuran; dichloromethane;
1.1: Substitution / 1.2: Substitution / 2.1: Reduction / 3.1: Alkylation;
DOI:10.1021/jo9918394
