36721-61-6

Usage

Uses

Used in Organic Synthesis:
1-methyl-2-oxo-1,2-dihydr... is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for versatile chemical reactions, facilitating the synthesis of complex molecules and pharmaceutical agents.
Used in Pharmaceutical Industry:
1-methyl-2-oxo-1,2-dihydr... is utilized as a key component in the development of pharmaceutical drugs. Its molecular structure may contribute to the modulation of biological pathways, offering potential therapeutic benefits in the treatment of various diseases and conditions.
Used in Chemical Research:
1-methyl-2-oxo-1,2-dihydr... serves as a valuable research tool in the field of chemistry. Its unique properties and reactivity can provide insights into the mechanisms of chemical reactions and the behavior of similar compounds, advancing the understanding of chemical processes and the discovery of new applications.

Upstream product

• 10072-09-0 3-(acetoxymethyl)pyridine 
• 77-78-1 dimethyl sulfate 
• 42463-41-2 3-(hydroxymethyl)pyridine-2(1H)-one 
• 74-88-4 methyl iodide 
• 15506-18-0 1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 
• 100-55-0 3-hydroxymethylpyridin 
• 36404-89-4 2-oxo-1,2-dihydro-pyridine-3-carbaldehyde 
• 79138-28-6 1-methyl-2-oxo-1,2-dihydropyridine-3-carbaldehyde 
• 183274-22-8 trimethylsilyl 2-(trimethylsilyloxy)nicotinate 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 67367-27-5 methyl 1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate 

Downstream Products

• 51417-15-3 3-(chloromethyl)-1-methylpyridin-2(1H)-one 
• 267401-02-5 benzyl (3-[1-methyl-2-oxo-(1H)-pyridinyl])-methyl ether 

Relevant academic research and scientific papers

Tether-enforced reversal of regioselectivity: Head-to-head [4 + 4] photocycloaddition of 2-pyridones

Symmetric 3,3′-attachment of a three-atom chain between two pyridones overrides the head-to-tail regioselectivity found in intermolecular photodimerization reactions and gives a nearly quantitative yield of the head-to-head [4 + 4] cycloadduct containing contiguous quaternary centres.

Triazolopyridazine derivative as well as preparation method, pharmaceutical composition and application thereof

The invention relates to triazolopyridazine derivatives as well as a preparation method, a pharmaceutical composition and application thereof. The invention provides a compound shown in a general formula (I), cis-trans isomers, enantiomers, diastereoisomers, racemes, solvates, hydrates or pharmaceutically acceptable salts or prodrugs of the compound, and a preparation method of the compound, the cis-trans isomers, the enantiomers, the diastereoisomers, the racemes, the solvates, the hydrates or the pharmaceutically acceptable salts or the prodrugs of the compound; preparation method thereof; pharmaceutical compositions containing the compounds, and the use of the compounds as alpha 5-GABAA receptor modulators, wherein R 1, R 2, and Z are as defined in the specification. pharmaceutical compositions containing the compounds and application of the compounds as alpha-5-GABAA receptor modulators, wherein R1, R2 and Z are as defined in the specification.

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.

Photoreactivity of 2-pyridones with furan, benzene, and naphthalene. Inter- and intramolecular photocycloadditions

Pyridones, well-known for their ability to photodimerize, have been found to undergo [4 + 4] photocycloaddition with furan and naphthalene but not with benzene. In some cases these reactions can be highly regio- and stereospecific. Intramolecular reaction with furan produces both cis and trans [4 + 4] products. The cycloaddition with naphthalene can occur both inter- and intramolecularly. The intermolecular reaction yields primarily the cis isomer, whereas the trans isomer is the major product from the intramolecular reaction. A mixture of 4-methoxy-2-pyridone and 2- methoxynaphthalene that could form up to eight regio- and stereoisomers forms largely one [4 + 4] product.