2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride

Base Information

Chemical Name:2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride
CAS No.:1372180-40-9
Molecular Formula:C₁₄H₁₉Cl₂NO₂*ClH
Molecular Weight:340.677
Hs Code.:

Synonyms:2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride

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Chemical Property of 2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride

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Technology Process of 2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride

There total 13 articles about 2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372187-53-5
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-(1-hydroxy-1-methylethyl)-1,4-oxazepane-4-carboxylate

: 1372180-40-9
2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 10 - 35 ℃;

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1372180-40-9
2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride

Guidance literature:: Multi-step reaction with 14 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 48 h / 10 - 35 °C

2.1: triethylamine / methanol / 72 h / 10 - 35 °C

3.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice

3.2: 0.5 h

4.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

6.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

7.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

7.2: 2 h / -78 - 35 °C

8.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

8.2: 18 h / 80 °C

8.3: 2 h / 35 °C / Cooling with ice

9.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

10.1: Dess-Martin periodane / acetonitrile / 3 h / Cooling with ice

11.1: 2-methyl-but-2-ene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 2 h / Cooling with ice

12.1: methanol / hexane / 0.5 h / 0 °C

13.1: diethyl ether; tetrahydrofuran / 3 h / -78 °C

13.2: -78 °C

14.1: hydrogenchloride / ethyl acetate / 10 - 35 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; hydrogenchloride; methanol; aluminum (III) chloride; sodium chlorite; sodium tetrahydroborate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; carbonochloridic acid 1-chloro-ethyl ester; Dess-Martin periodane; triethylamine; calcium chloride; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;

Reference yield:

: methyl 2-[(3,4-dichlorophenyl)(hydroxy)methyl]prop-2-enoate

: 1372180-40-9
2-[(6R,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]propan-2-ol monohydrochloride

Guidance literature:: Multi-step reaction with 13 steps

1.1: triethylamine / methanol / 72 h / 10 - 35 °C

2.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice

2.2: 0.5 h

3.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

4.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

5.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

6.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

6.2: 2 h / -78 - 35 °C

7.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

7.2: 18 h / 80 °C

7.3: 2 h / 35 °C / Cooling with ice

8.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

9.1: Dess-Martin periodane / acetonitrile / 3 h / Cooling with ice

10.1: 2-methyl-but-2-ene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 2 h / Cooling with ice

11.1: methanol / hexane / 0.5 h / 0 °C

12.1: diethyl ether; tetrahydrofuran / 3 h / -78 °C

12.2: -78 °C

13.1: hydrogenchloride / ethyl acetate / 10 - 35 °C

With 1H-imidazole; hydrogenchloride; methanol; aluminum (III) chloride; sodium chlorite; sodium tetrahydroborate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; carbonochloridic acid 1-chloro-ethyl ester; Dess-Martin periodane; triethylamine; calcium chloride; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;