Technology Process of (6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-6-carboxylic acid
There total 14 articles about (6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-6-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate;
In
tetrahydrofuran; water; tert-butyl alcohol;
at 0 ℃;
for 2h;
DOI:10.1016/j.bmc.2015.05.017
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: triethylamine / methanol / 72 h / 10 - 35 °C
2.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice
2.2: 0.5 h
3.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice
4.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C
5.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice
6.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere
6.2: 2 h / -78 - 35 °C
7.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C
7.2: 18 h / 80 °C
7.3: 2 h / 35 °C / Cooling with ice
8.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate
9.1: Dess-Martin periodane / acetonitrile / 3 h / Cooling with ice
10.1: 2-methyl-but-2-ene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 2 h / Cooling with ice
With
1H-imidazole; aluminum (III) chloride; sodium chlorite; sodium tetrahydroborate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; carbonochloridic acid 1-chloro-ethyl ester; Dess-Martin periodane; triethylamine; calcium chloride; sodium t-butanolate;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 48 h / 10 - 35 °C
2.1: triethylamine / methanol / 72 h / 10 - 35 °C
3.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice
3.2: 0.5 h
4.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice
5.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C
6.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice
7.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere
7.2: 2 h / -78 - 35 °C
8.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C
8.2: 18 h / 80 °C
8.3: 2 h / 35 °C / Cooling with ice
9.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate
10.1: Dess-Martin periodane / acetonitrile / 3 h / Cooling with ice
11.1: 2-methyl-but-2-ene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 2 h / Cooling with ice
With
1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; aluminum (III) chloride; sodium chlorite; sodium tetrahydroborate; potassium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; carbonochloridic acid 1-chloro-ethyl ester; Dess-Martin periodane; triethylamine; calcium chloride; sodium t-butanolate;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; water; acetonitrile; tert-butyl alcohol;
