2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one

Base Information

Chemical Name:2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
CAS No.:1062609-33-9
Molecular Formula:C₂₁H₂₂F₃N₃O₃
Molecular Weight:421.419
Hs Code.:

Synonyms:2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one

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Chemical Property of 2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one

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Technology Process of 2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one

There total 3 articles about 2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1062617-27-9
1-(4-(difluoromethoxy)-3-methylphenyl)-2-(4-fluoro-3-isopropoxyphenyl)ethane-1,2-dione

: 22661-87-6,21770-81-0
1-methylguanidine hydrochloride

: 1062609-33-9
2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one

Guidance literature:: With sodium carbonate; In ethanol; at 85 ℃; for 15h;

Reference yield:

: 1062617-22-4
5-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-2-fluorophenol

: 1062609-33-9
2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / butanone / Heating / reflux

2: potassium permanganate; sodium hydrogencarbonate; magnesium sulfate / water; acetone / 2 h

3: sodium carbonate / ethanol / 15 h / 85 °C

With potassium permanganate; sodium hydrogencarbonate; sodium carbonate; magnesium sulfate; caesium carbonate; In ethanol; water; acetone; butanone;

Reference yield:

: 1062617-25-7
1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene

: 1062609-33-9
2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-5-(4-fluoro-3-isopropoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium permanganate; sodium hydrogencarbonate; magnesium sulfate / water; acetone / 2 h

2: sodium carbonate / ethanol / 15 h / 85 °C

With potassium permanganate; sodium hydrogencarbonate; sodium carbonate; magnesium sulfate; In ethanol; water; acetone;