1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene

Base Information

Chemical Name:1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene
CAS No.:1062617-25-7
Molecular Formula:C₁₉H₁₇F₃O₂
Molecular Weight:334.338
Hs Code.:

Synonyms:1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene

Chemical Property:

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Technology Process of 1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene

There total 3 articles about 1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 75-30-9
2-iodo-propane

: 1062617-22-4
5-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-2-fluorophenol

: 1062617-25-7
1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene

Guidance literature:: With caesium carbonate; In butanone; Heating / reflux;

Reference yield:

: 1062613-63-1
1-(difluoromethoxy)-4-iodo-2-methylbenzene

: 1062617-25-7
1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 20 °C

2: caesium carbonate / butanone / Heating / reflux

With caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; butanone;

Reference yield:

: 60577-30-2
4-iodo-2-methyl-phenol

: 1062617-25-7
1-(difluoromethoxy)-4-((4-fluoro-3-isopropoxyphenyl)ethynyl)-2-methylbenzene

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / water; N,N-dimethyl-formamide / 12 h / 120 °C

2: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 20 °C

3: caesium carbonate / butanone / Heating / reflux

With potassium carbonate; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In water; N,N-dimethyl-formamide; butanone;