ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

Base Information

Chemical Name:ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate
CAS No.:1365038-46-5
Molecular Formula:C₂₅H₂₅Cl₃N₄O₃
Molecular Weight:535.857
Hs Code.:

Synonyms:ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

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Chemical Property of ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

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Technology Process of ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

There total 4 articles about ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1365038-22-7
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-[(3S)-piperidin-3-yl]-1H-pyrazole-3-carboxamide

: 541-41-3
chloroformic acid ethyl ester

: 1365038-46-5
ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm201731z

Reference yield:

: 625471-18-3
tert-butyl (3S)-3-aminopiperidine-1-carboxylate

: 1365038-46-5
ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / Inert atmosphere

3: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201731z

Reference yield:

: 162758-35-2
rimonabant acid

: 1365038-46-5
ethyl (3S)-3-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / Inert atmosphere

3: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201731z