Technology Process of (R,Z)-tert-butyl 2-(9-((2,4-difluorophenyl)ethynyl)-7-oxo-2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine-6-carboxamido)-3-(isobutylthio)-propanoate
There total 13 articles about (R,Z)-tert-butyl 2-(9-((2,4-difluorophenyl)ethynyl)-7-oxo-2,5,6,7-tetrahydrobenzo[b][1,5]oxazonine-6-carboxamido)-3-(isobutylthio)-propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane;
for 2h;
Inert atmosphere;
Reflux;
DOI:10.1039/c2ob25618e
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap; di-tert-butyl dicarbonate / 16 h / 20 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane / 0.5 h / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C / Inert atmosphere
4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / Inert atmosphere; Reflux
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; dmap; di-tert-butyl dicarbonate; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1039/c2ob25618e
- Guidance literature:
-
Multi-step reaction with 7 steps
1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
2: water; lithium hydroxide / methanol / 12 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere
4: triethylamine / diethyl ether / 1 h / 20 °C / Inert atmosphere
5: diethyl ether; toluene / 1 h / 0 - 20 °C / Inert atmosphere
6: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C / Inert atmosphere
7: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / Inert atmosphere; Reflux
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/c2ob25618e
