(R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate

Base Information

Chemical Name:(R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate
CAS No.:1385774-87-7
Molecular Formula:C₃₃H₃₈F₂N₂O₅S
Molecular Weight:612.738
Hs Code.:

Synonyms:(R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate

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Chemical Property of (R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate

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Technology Process of (R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate

There total 11 articles about (R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1385774-96-8
C₁₁H₂₃NO₂S*ClH

: C₂₂H₁₆ClF₂NO₃

: 1385774-87-7
(R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1039/c2ob25618e

Reference yield:

: 873330-41-7
(R)-N-(tert-butyloxycarbonyl)-S-(isobutyl)cysteine

: 1385774-87-7
(R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; di-tert-butyl dicarbonate / 16 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 0.5 h / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; di-tert-butyl dicarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1039/c2ob25618e

Reference yield:

: 1385774-73-1
ethyl 5-(2-(2,4-difluorophenyl)ethynyl)-2-hydroxybenzoate

: 1385774-87-7
(R)-tert-butyl 2-(3-allyl-3-(2-(allyloxy)-5-((2,4-difluorophenyl)-ethynyl)benzoyl)ureido)-3-(isobutylthio)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

2: water; lithium hydroxide / methanol / 12 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

4: triethylamine / diethyl ether / 1 h / 20 °C / Inert atmosphere

5: diethyl ether; toluene / 1 h / 0 - 20 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1039/c2ob25618e