methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate

Base Information

• Chemical Name: methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate
• CAS No.: 857903-60-7
• Molecular Formula: C₁₉H₁₇ClN₂O₃
• Molecular Weight: 356.809
• Mol file: 857903-60-7.mol

Synonyms:methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate

Chemical Property of methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate

There total 4 articles about methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 3-(4-hydroxyohenyl)-2-methylpropionate (81579-29-5) + 2,7-dichloroquinoxaline (59489-31-5) → methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate (857903-60-7)

Guidance literature:

With potassium carbonate; In acetonitrile; for 4h; Heating;

DOI:10.1016/j.bmc.2005.04.011

Reference yield:

rac-3-(4-hydroxyphenyl)-2-methylpropanoic acid (35456-48-5) → methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate (857903-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / H₂SO₄ / Heating

2: 92 percent / K₂CO₃ / acetonitrile / 4 h / Heating

With sulfuric acid; potassium carbonate; In acetonitrile;

DOI:10.1016/j.bmc.2005.04.011

Reference yield:

(E)-3-(4-hydroxyphenyl)-2-methyl-prop-2-enoic acid (113277-24-0,5325-37-1) → methyl 3-{4-[(7-chloro-2-quinoxalinyl)oxy]phenyl}-2-methylpropionate (857903-60-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminium-nickel alloy; NaOH / H₂O

2: 99 percent / H₂SO₄ / Heating

3: 92 percent / K₂CO₃ / acetonitrile / 4 h / Heating

With sodium hydroxide; aluminium-nickel alloy; sulfuric acid; potassium carbonate; In water; acetonitrile;

DOI:10.1016/j.bmc.2005.04.011

upstream raw materials:

methyl 3-(4-hydroxyohenyl)-2-methylpropionate

2,7-dichloroquinoxaline

rac-3-(4-hydroxyphenyl)-2-methylpropanoic acid

(E)-3-(4-hydroxyphenyl)-2-methyl-prop-2-enoic acid