4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone

Base Information

Chemical Name:4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone
CAS No.:1370262-88-6
Molecular Formula:C₂₂H₂₃Cl₂F₃N₄O
Molecular Weight:487.352
Hs Code.:

Synonyms:4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone

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Chemical Property of 4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone

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Technology Process of 4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone

There total 5 articles about 4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1370263-09-4
4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde

: 1-ammonium-3-ethyl urea hydrochloride

: 1370262-88-6
4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone

Guidance literature:: With acetic acid; In ethanol; at 70 ℃; for 4h;

Reference yield:

: 1025025-18-6
1-benzyl-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

: 1370262-88-6
4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 20 - 25 °C / Reflux

1.2: 2 h / Reflux

2.1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / Inert atmosphere; Reflux

3.1: diisobutylaluminium hydride / toluene / -40 - 0 °C

4.1: acetic acid / ethanol / 4 h / 70 °C

With carbonochloridic acid 1-chloro-ethyl ester; diisobutylaluminium hydride; acetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; dichloromethane; toluene;

Reference yield:

: 1025025-19-7
rac-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

: 1370262-88-6
4-[3-(3,5-dichloro-phenyl)-3-trifluoromethyl-pyrrolidin-1-yl]-2-methyl-benzaldehyde-ethylsemicarbazone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / Inert atmosphere; Reflux

2: diisobutylaluminium hydride / toluene / -40 - 0 °C

3: acetic acid / ethanol / 4 h / 70 °C

With diisobutylaluminium hydride; acetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; toluene;