1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

Base Information

• Chemical Name: 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene
• CAS No.: 864725-22-4
• Molecular Formula: C9H5Cl2F3
• Molecular Weight: 241.04
• Hs Code.: 2903999090
• Mol file: 864725-22-4.mol

Synonyms:1,3-dichloro-5-(1-trifluoromethyl-vinyl)-benzene;2-(3,5-dichlorophenyl)-3,3,3-trifluoro-1-propene;

Chemical Property of 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

Chemical Property:

• Boiling Point: 265.6±40.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.373±0.06 g/cm3(Predicted)
• LogP: 4.56890
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

There total 9 articles about 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + (3,5-dichlorophenyl)boronic acid (67492-50-6) → 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4)

Guidance literature:

With potassium carbonate; (1,4-naphthoquinone)-[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 5h; Product distribution / selectivity; Inert atmosphere;

Reference yield: 89.5%

2-bromo-3,3,3-trifluoropropene (1514-82-5) + 3,5-Dichloroaniline (626-43-7) → 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4)

Guidance literature:

3,5-Dichloroaniline; With bis(pinacol)diborane; dibenzoyl peroxide; In 1,4-dioxane; at 25 ℃; for 4h; Inert atmosphere;

2-bromo-3,3,3-trifluoropropene; With sodium dihydrogenphosphate; bis(tricyclohexylphosphine)nickel(II) dichloride; In 1,4-dioxane; at 25 ℃; for 5h; Solvent; Reagent/catalyst; Inert atmosphere;

Reference yield: 79.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 3,5-dichloro-2,2,2-trifluoroacetophenone (130336-16-2) → 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (864725-22-4)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 - 25 ℃; for 1.5h;

upstream raw materials:

2-bromo-3,3,3-trifluoropropene

(3,5-dichlorophenyl)boronic acid

1,1,1-trifluoropropylene

Methyltriphenylphosphonium bromide

Downstream raw materials:

methyl 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]benzoate

ethyl 2-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-4-methyl-5-pyrimidinecarboxylate

3-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]nitrobenzene

N-(3-(5-(3,5-dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-isoxazol-3-yl)-2-methyl-phenyl)-3,3,3-trifluoro-propanamide