tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate

Base Information

Chemical Name:tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate
CAS No.:337308-86-8
Molecular Formula:C₄₀H₅₈O₁₁P₂
Molecular Weight:776.841
Hs Code.:

Synonyms:tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate

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Chemical Property of tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate

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Technology Process of tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate

There total 7 articles about tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 37465-31-9
1,1-bis(diethylphosphono)ethylene

: 337308-85-7
17β-(3-benzyloxyoestra-1,3,5(10)-trienyl) ethyl malonate

: 337308-86-8
tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0040-4020(00)01164-9

Reference yield:

: 1660-94-2
Tetraethyl methylenediphosphonate

: 337308-86-8
tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₂NH / 0.5 h / Heating

2: 43.16 g / toluene-p-sulfonic acid / methanol / Heating

3: 30 percent / Et₃N / CH₂Cl₂ / 20 °C

With toluene-4-sulfonic acid; diethylamine; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(00)01164-9

Reference yield:

: 53-16-7
Estrone

: 337308-86-8
tetraethyl (17β (3-benzyloxyoestra-1,3,5(10)-trienyl)oxycarbonyl) (ethoxycarbonyl) propylene bisphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / K₂CO₃ / acetone / 20 °C

2: 89 percent / NaBH₄ / methanol; CH₂Cl₂ / 3 h / 0 °C

3: 46 percent / dicyclohexylcarbodiimide; 4-(N,N-dimethylamino)pyridine / diethyl ether / 18 h / 20 °C

4: 30 percent / Et₃N / CH₂Cl₂ / 20 °C

With dmap; sodium tetrahydroborate; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In methanol; diethyl ether; dichloromethane; acetone;
DOI:10.1016/S0040-4020(00)01164-9