4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile

Base Information

• Chemical Name: 4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile
• CAS No.: 868596-02-5
• Molecular Formula: C₁₃H₁₀FN₅O₂
• Molecular Weight: 287.253
• Mol file: 868596-02-5.mol

Synonyms:4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile

Chemical Property of 4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile

There total 2 articles about 4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,4-difluoro-5-nitrobenzonitrile (67152-20-9) + 3-amino-5-cyclopropyl-1H-pyrazole (175137-46-9) → 4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile (868596-02-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 25 ℃; for 1h;

Reference yield:

2,4-difluorobenzonitrile (3939-09-1,103496-86-2) → 4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile (868596-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; potassium nitrate / water / 4 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 25 °C

With sulfuric acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water;

Reference yield: 97.0%

4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-fluoro-5-nitrobenzonitrile (868596-02-5) + (S)-1-(4-Fluoro-phenyl)-ethylamine (66399-30-2) → (S)-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-[1-(4-fluoro-phenyl)-ethylamino]-5-nitro-benzonitrile

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 230 ℃; for 2h;

upstream raw materials:

2,4-difluoro-5-nitrobenzonitrile

3-amino-5-cyclopropyl-1H-pyrazole

2,4-difluorobenzonitrile