175137-46-9

Basic information

• Product Name: 5-CYCLOPROPYL-2H-PYRAZOL-3-YLAMINE
• Synonyms: 3-AMINO-5-CYCLOPROPYL-2H-PYRAZOLE;TIMTEC-BB SBB005482;5-Amino-3-cyclopropylpyrazole;3-Cyclopropyl-1H-pyrazol-5-amine ,98%;3-Cyclopropylpyrazol-5-amine;3-Amino-5-cyclopropyl-1H-pyrazole, 96%;3-Cyclopropyl-1H-pyrazol-5-amine ,94%;3-AMino-5-cyclopropyl-1H-...
• CAS NO: 175137-46-9
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.16
• Product Categories: Amines;Pyrazoles & Triazoles;Pyrazoles & Triazoles
• Mol File: 175137-46-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 367.529 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.159 g/mL at 25 °C
• Vapor Pressure: 1.36E-05mmHg at 25°C
• Refractive Index: n20/D1.566
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.84±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 5-CYCLOPROPYL-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYCLOPROPYL-2H-PYRAZOL-3-YLAMINE(175137-46-9)
• EPA Substance Registry System: 5-CYCLOPROPYL-2H-PYRAZOL-3-YLAMINE(175137-46-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38-25
• Safety Statements: 26-36/37/39-45-36
• RIDADR: UN1760
• WGK Germany: 3
• Hazardous Substances Data: 175137-46-9(Hazardous Substances Data)

Usage

Physical Form

Liquid

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

InChI:InChI=1/C6H9N3/c7-6-3-5(8-9-6)4-1-2-4/h3-4H,1-2H2,(H3,7,8,9)

Upstream product

• 118431-88-2 3-cyclopropyl-3-oxo-propionitrile 

Downstream Products

• 438203-16-8 (5-cyclopropyl-1H-pyrazol-3-yl)-(2-phenoxymethyl-quinazolin-4-yl)-amine 
• 868596-03-6 5-cyclopropyl-N-(2,3-difluoro-6-nitrophenyl)-1H-pyrazol-3-amine 
• 918538-08-6 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine 
• 851435-00-2 2-chloro-N-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidin-4-amine 
• 918538-08-6 2-chloro-N-(3-cyclopropyl-1H-pyrazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine 

Relevant articles and documents

2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof

The invention relates to 2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof. Specifically, the invention discloses the compounds represented by a formula (I) shown in the specification, enantiomers, diastereomers, racemates or a mixture of the compounds, or a pharmaceutically acceptable salt, hydrate and solvate of the compounds, a preparation method of the above materials, and applications of the above materials in preparation of an ASK1 small molecule inhibitor, or medicines for preventing and/or treating diseases related to ASK1, especially liver diseases, lung diseases, cardiovascular diseases, kidney diseases and metabolic diseases.

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor.

BENZENE SULFONAMIDES AS CCR9 INHIBITORS

The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).