Technology Process of 3-(2,2-dibromovinyl)-4-hydroxybenzonitrile
There total 2 articles about 3-(2,2-dibromovinyl)-4-hydroxybenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
carbon tetrabromide;
With
triphenylphosphine;
In
dichloromethane;
at 0 ℃;
for 0.25h;
5-cyanosalicylaldehyde;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide / 5 h / 150 °C / Inert atmosphere
2.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C
2.2: 2 h / 0 °C
With
triphenylphosphine;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium phosphate; copper(l) iodide / tetrahydrofuran / 3 h / 80 °C / Inert atmosphere
2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / toluene; ethanol / 3 h / 80 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 20 °C
4: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C
With
4-methyl-morpholine; potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; HATU;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
