(tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

Base Information

Chemical Name:(tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide
CAS No.:98482-76-9
Molecular Formula:C₃₅H₄₈N₆O₇
Molecular Weight:664.802
Hs Code.:

Synonyms:(tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

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Technology Process of (tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

There total 6 articles about (tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 3392-11-8
2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate

: 98482-74-7
(S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

: 98482-76-9
(tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 4h; Ambient temperature;
DOI:10.1021/jm00150a020

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 98482-76-9
(tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / sodium cyanoborohydride / methanol; acetic acid / 3 h

2: H₂, HCl / 10 percent Pd/C / ethanol / 4 h

3: 55 percent / N,N-diisopropylethylamine (DIEA) / dimethylformamide / Ambient temperature

4: trifluoroacetic acid (TFA) / 1 h

5: 53 percent / N,N-diisopropylethylamine (DIEA) / dimethylformamide / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a020

Reference yield:

: 98482-71-4
(benzyloxycarbonyl)-β-tert-butyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

: 98482-76-9
(tert-butyloxycarbonyl)-L-tryptophyl-leucyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, HCl / 10 percent Pd/C / ethanol / 4 h

2: 55 percent / N,N-diisopropylethylamine (DIEA) / dimethylformamide / Ambient temperature

3: trifluoroacetic acid (TFA) / 1 h

4: 53 percent / N,N-diisopropylethylamine (DIEA) / dimethylformamide / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a020