(S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

Base Information

Chemical Name:(S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid
CAS No.:98482-74-7
Molecular Formula:C₁₉H₃₀N₄O₄
Molecular Weight:378.472
Hs Code.:

Synonyms:(S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

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Chemical Property of (S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

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Technology Process of (S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

There total 5 articles about (S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 98482-74-7
(S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / sodium cyanoborohydride / methanol; acetic acid / 3 h

2: H₂, HCl / 10 percent Pd/C / ethanol / 4 h

3: 55 percent / N,N-diisopropylethylamine (DIEA) / dimethylformamide / Ambient temperature

4: trifluoroacetic acid (TFA) / 1 h

With hydrogenchloride; hydrogen; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a020

Reference yield:

: 98482-71-4
(benzyloxycarbonyl)-β-tert-butyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

: 98482-74-7
(S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂, HCl / 10 percent Pd/C / ethanol / 4 h

2: 55 percent / N,N-diisopropylethylamine (DIEA) / dimethylformamide / Ambient temperature

3: trifluoroacetic acid (TFA) / 1 h

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a020

Reference yield:

: 3392-09-4
Boc-Leu-ONSu

: 98482-74-7
(S)-3-((S)-2-Amino-4-methyl-pentanoylamino)-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / N,N-diisopropylethylamine (DIEA) / dimethylformamide / Ambient temperature

2: trifluoroacetic acid (TFA) / 1 h

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a020