3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine

Base Information

Chemical Name:3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine
CAS No.:1332507-55-7
Molecular Formula:C₄₂H₆₂N₄O₁₀Si₂
Molecular Weight:839.146
Hs Code.:

Synonyms:3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine

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Chemical Property of 3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine

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Technology Process of 3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine

There total 10 articles about 3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1332507-69-3
3-(2'-deoxy-D-ribofuranosyl)-9-(2-N-benzylcarbamylethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1332507-55-7
3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.111

Reference yield:

: 1332507-68-2
4-O-pivaloyl-2-aminophloroglucinol

: 1332507-55-7
3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 0.5 h / 20 °C

4: triethylamine / ethanol / 54 h / 80 °C / Inert atmosphere

5: 1H-imidazole; dmap / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; di-isopropyl azodicarboxylate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.03.111

Reference yield:

: C₁₁H₁₃NO₆

: 1332507-55-7
3-(3',5'-di-O-tert-butyl-dimethyl-silane-d-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-pivaloyl-2-oxophenoxadine

Guidance literature:: Multi-step reaction with 6 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 2.5 h / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 24 h / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 0.5 h / 20 °C

5: triethylamine / ethanol / 54 h / 80 °C / Inert atmosphere

6: 1H-imidazole; dmap / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; di-isopropyl azodicarboxylate; 5%-palladium/activated carbon; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 3: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.03.111