(S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:80601-74-7
Molecular Formula:C₃₁H₃₈N₂O₇
Molecular Weight:550.652
Hs Code.:

Synonyms:(S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about (S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 30354-18-8
N,N-dimethyl(methylene)ammonium chloride

: 80734-20-9
(S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

: 80601-74-7
(S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With triethylamine; In acetonitrile; for 6h; Ambient temperature;
DOI:10.1248/cpb.29.2816

Reference yield:

: 30418-38-3
(-)-Trimetoquinol

: 80601-74-7
(S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / NaHCO₃ / CHCl₃; H₂O / 1 h / 5 °C / then 2 h room temperature

2: 93 percent / Et₃N / acetonitrile / 1 h / 0 °C

3: 1.) Me₂SO₄, 2.) NaBH₃CN / 1.) HMPA, 50 deg C, 1.5 h, 2.) HMPA, 70 deg C, 2 h

4: 95 percent / Et₃N / acetonitrile / 6 h / Ambient temperature

With sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; dimethyl sulfate; In chloroform; water; acetonitrile;
DOI:10.1248/cpb.29.2816

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 80601-74-7
(S)-N-benzyloxycarbonyl-6,7-dihydroxy-5-methyl-8-dimethylaminomethyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / NaHCO₃ / CHCl₃; H₂O / 1 h / 5 °C / then 2 h room temperature

2: 93 percent / Et₃N / acetonitrile / 1 h / 0 °C

3: 1.) Me₂SO₄, 2.) NaBH₃CN / 1.) HMPA, 50 deg C, 1.5 h, 2.) HMPA, 70 deg C, 2 h

4: 95 percent / Et₃N / acetonitrile / 6 h / Ambient temperature

With sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; dimethyl sulfate; In chloroform; water; acetonitrile;
DOI:10.1248/cpb.29.2816