Dimethylmethylenammonium chloride

Base Information

• Chemical Name: Dimethylmethylenammonium chloride
• CAS No.: 30354-18-8
• Molecular Formula: C3H8 N . Cl
• Molecular Weight: 93.5562
• Hs Code.: 2923900090
• European Community (EC) Number: 250-142-4
• DSSTox Substance ID: DTXSID60952697
• Mol file: 30354-18-8.mol

Synonyms:30354-18-8;Dimethylmethylenammonium chloride;N,N-Dimethylmethyleneiminium chloride;Dimethylformiminium chloride;dimethyl(methylidene)azanium;chloride;dimethyl(methylidene)azanium chloride;EINECS 250-142-4;N,N-dimethyl(methylene)ammonium chloride;N,N-dimethyl-methylene ammonium chloride;Methylenedimethylammonium chloride;C3H8N.Cl;C3-H8-N.Cl;Methanaminium, N-methyl-N-methylene-, chloride (9CI);DTXSID60952697;ZJTROANVDZIEGB-UHFFFAOYSA-M;Dimethyl(methylene)iminium chloride;dimethyl-methylene-ammonium chloride;MFCD00011809;N,N-dimethyl-methylenammonium chloride;n-methyl-n-methylenemethanaminiumchloride;n-methyl-n-methylenemethanaminium chloride;DIMETHYL(METHYLENE)AMMONIUM CHLORIDE;n-methyl-n-methylene-methaneaminium chloride;BB 0263006;Methanaminium, N-methyl-N-methylene-, chloride;J-017923

Chemical Property of Dimethylmethylenammonium chloride

Chemical Property:

• Melting Point: 146-148 °C(lit.)
• Flash Point: 180 °F
• PSA: 3.01000
• LogP: -3.03690
• Storage Temp.: Store below +30°C.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 93.0345270
• Heavy Atom Count: 5
• Complexity: 26.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-DimethylmethyleneiminiumChloride(TechnicalGrade) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[N+](=C)C.[Cl-]
• Uses: N,N-Dimethylmethyleneiminium chloride (B?hme′s salt) is a dimethylaminomethylating agent that can be used as one of the key reagents in the following applications:Electrophilic aminomethylation of aldehydes and ketones to synthesize corresponding Mannich products, also known as Mannich reaction.Preparation of dihydronaphthyridinones as HIV-1 integrase inhibitors.Preparation of cyanotetrahydrooxo-β-carbolines via cyclocondensation of cyanomethyl indole-2-carboxylate with ammonia.Asymmetric synthesis of phalarine via stereospecific Pictet-Spengler cyclocondensation and traceless chirality transfer from L-tryptophan.Synthesis of functionalized diarylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX).Synthesis of (±)-phalarine with the rearrangement of an azaspiroindolenine and Gassman oxindole preparation as key steps.

Technology Process of Dimethylmethylenammonium chloride

There total 14 articles about Dimethylmethylenammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bis-(dimethylamino)methane (51-80-9) → N,N-dimethyl(methylene)ammonium chloride (30354-18-8)

Guidance literature:

With acetyl chloride; In diethyl ether; for 2h;

Reference yield: 100.0%

N,N′-dimethyl-1,2-ethanediamine → N,N-dimethyl(methylene)ammonium chloride (30354-18-8)

Guidance literature:

With acetyl chloride; In diethyl ether; for 2h;

Reference yield: 98.0%

ethoxy-N,N-dimethylaminomethane (62992-33-0) → N,N-dimethyl(methylene)ammonium chloride (30354-18-8)

Guidance literature:

With Methyltrichlorosilane; In acetonitrile; for 0.0833333h;

DOI:10.1055/s-1986-31627

upstream raw materials:

bis-(dimethylamino)methane

formaldehyd

N,N-Dimethyltrimethylsilylamine

methoxy bis(dimethylamino)methane

Downstream raw materials:

Benzoesaeure-

3-dimethylamino-2,2-dimethylpropanal

Dimethylaminomethyl-dicyclohexylphosphin

(furan-2-ylmethyl)dimethylamine

Refernces

• 1、 Antipin,Bodrikov,Nikitina,Fukin. "Reactions of hexamethylphosphoramide with sulfur dichloride with the ambivalent participation of methylene chloride". . p. 216 - 219. Retrieved 2008.
• 2、 Bodrikov,Shebelova,Nikitina. "Sulfur dichloride-hexamethylphosphoric triamide complex -A reagent for imination of geminal dichlorides". . p. 619 - 620. Retrieved 2008.
• 3、 -. "3-(dimethylaminomethyl) piperidine-4-alcohol derivative as well as preparation method and pharmaceutical application thereof". Paragraph 0073-0077. . Retrieved 2021/05/08.
• 4、 -. "3-(dimethylaminomethyl) piperidine-4-alcohol derivative as well as preparation method and pharmaceutical application thereof". Paragraph 0075-0078. . Retrieved 2021/05/08.