C₁₈H₁₄F₄N₂O

Base Information

Chemical Name:C₁₈H₁₄F₄N₂O
CAS No.:1346641-85-7
Molecular Formula:C₁₈H₁₄F₄N₂O
Molecular Weight:350.316
Hs Code.:

C<sub>18</sub>H<sub>14</sub>F<sub>4</sub>N<sub>2</sub>O

Synonyms:C₁₈H₁₄F₄N₂O

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Chemical Property of C₁₈H₁₄F₄N₂O

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Technology Process of C₁₈H₁₄F₄N₂O

There total 6 articles about C₁₈H₁₄F₄N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1346640-97-8
N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-methylcyclopropanecarboxamide

: 141091-37-4
2-(cyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1346641-85-7
C₁₈H₁₄F₄N₂O

: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2-(cyclohex-1-enyl)-1-methylcyclopropanecarboxamide

Guidance literature:: With palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In tetrahydrofuran; at 100 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ja207607s

Reference yield:

: 1346641-14-2
C₉H₁₆O₂

: 1346641-85-7
C₁₈H₁₄F₄N₂O

: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2-(cyclohex-1-enyl)-1-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / 1,4-dioxane / 20 °C

2: oxalyl dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3: toluene / 12 h / Reflux

4: palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone / tetrahydrofuran / 6 h / 100 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; water; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/ja207607s

Reference yield:

: 773-82-0
Pentafluorobenzonitrile

: 1346641-85-7
C₁₈H₁₄F₄N₂O

: N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2-(cyclohex-1-enyl)-1-methylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / water; ethyl acetate / 6 h / 20 °C

2: toluene / 12 h / Reflux

3: palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone / tetrahydrofuran / 6 h / 100 °C / Inert atmosphere

With ammonia; palladium diacetate; sodium hydrogencarbonate; dimethyl sulfoxide; silver carbonate; p-benzoquinone; In tetrahydrofuran; water; ethyl acetate; toluene;
DOI:10.1021/ja207607s